It is a combination of hydralazine hydrochloride (an arteriolar vasodilator) and isosorbide dinitrate (a nitrate vasodilator )
[2] [1] It is taken by mouth or under the tongue
31 g/mol
BiDil Following a single 75-mg oral dose of hydralazine plus 40 mg of isosorbide dinitrate to 19 healthy adults, peak plasma concentrations of hydralazine (88 ng/mL/65 kg) and isosorbide dinitrate (76 ng/mL/65 kg) were reached in 1 hour
BiDil (isosorbide dinitrate and hydralazine hcl) is a combination of a nitrate and a vasodilator used as an adjunct therapy to treat heart failure in black patients to
Isosorbide dinitrate and hydralazine combination is used to treat heart failure in black patients
BiDil What is this drug used for? It is used to treat heart failure (weak heart)
This information from Lexicomp ® explains what you need to know about this medication, including what it’s used for, how to take it, its side effects, and when to
Find medical information for isosorbide dinitrate/hydralazine on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures
The BiDil (20 mg isosorbide dinitrate and 37
The safety and tolerability in individuals requiring maintenance hemodialysis (HD) is unknown
For treatment of heart failure: For oral dosage form (tablets): Adults—At first, one tablet three times a day
1 tab PO q8hr; titrate dose to effect; not to exceed 2 tab PO q8hr; may decrease dose to as little as 1/2 tab q8hr if intolerable side effects occur; as soon as side effects subside, effort
Isosorbide dinitrate belongs to the group of medicines called nitrates
By sublingual administration using aerosol spray
It is given in combination with other medicines to treat heart failure
May decrease as low as hydralazine 18
Call your doctor right away if you have burning, crawling, itching, numbness, prickling, "pins and needles", or Applies to: hydralazine / isosorbide dinitrate and Entresto (sacubitril / valsartan) Sacubitril may add to the blood pressure lowering effects of hydrALAZINE
5mg / isosorbide dinatrate 20mg PO TID
Frequent administration times, high pill burden, high incidence of adverse effects, slower titration increases tolerance
Two randomized, placebo-controlled trials have now
headache, severe and throbbing
Isosorbide dinitrate also comes as an injection or drip (infusion), which is given in hospital
Nitrates work by widening blood vessels (veins and arteries)
Isosorbide dinitrate is described chemically as 1,4:3,6-dianhydro-D-glucitol dinitrate and its structural formula is: difficult or labored breathing
lower back or side pain
Isosorbide dinitrate causes your arteries and veins to release nitric oxide
There is little experience in patients with NYHA* class IV heart failure
In contrast, body oxygen consumption at peak exercise was increased only by hydralazine–isosorbide dinitrate treatment (P<0
Hydralazine is believed to have both vasodilatory properties specific to the arteries and antioxidant properties, which address both the biochemical Although hemodynamic improvement was achieved with both forms of therapy, the beneficial effects of hydralazine alone or with isosorbide were superior to those of dopamine, as manifested by a greater reduction of wedge pressure and greater increase in stroke index