In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain)
Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones
1 Absorption
The pharmacokinetics and safety of duloxetine were evaluated in a single-blind, placebo-controlled, escalating multiple-dose study in 12 healthy male subjects
Duloxetine is a potent and balanced dual inhibitor of serotonin and norepinephrine reuptake being investigated for the treatment of depression and urinary
Duloxetine is a type of antidepressant known as a serotonin–norepinephrine reuptake inhibitor used to treat depression and anxiety
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For treatment of chronic muscle pain: Adults—60 milligrams (mg) once a day
Initial dose: 20 mg to 30 mg orally 2 times a day
Along with its needed effects, duloxetine may cause some unwanted effects
For stress urinary incontinence, duloxetine comes in 20mg and 40mg capsules
duloxetine increases levels of eliglustat by affecting hepatic enzyme CYP2D6 metabolism
Common side effects include feeling sick, a dry mouth, headache, constipation and feeling sleepy
The pharmacokinetics of duloxetine after a single dose of 40 mg were compared in healthy elderly females (65 to 77 years) and healthy middle-age females (32 to 50 years)
increased anxiety
Some of the common side effects of duloxetine will gradually improve as your body gets used to it
Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor
It's available as a generic drug and as the brand-name A pooled analysis of six different placebo-controlled research studies found that 44
Duloxetine has an elimination half-life of about 12 hours (range 8 to 17 hours) and its pharmacokinetics are dose proportional over the therapeutic range
Steady-state plasma concentrations are typically achieved after 3 days of dosing