The hepatotoxic profile of clarithromycin appears similar to that of erythromycin
Abstract The authors report a case of an acute toxic cholestatic reaction to clarithromycin, proven by liver biopsy, in a patient with comorbid diseases, prior exposure to
Acalculous cholecystitis is an acute necroinflammatory disease of the gallbladder with multifactorial pathogenesis, mostly observed in immunosuppressed
An objective causality assessment suggested that cholestasis was probably related to clarithromycin and/or nimesulide use
Frequency not reported: Acute cytolytic hepatitis, cholestatic jaundice, hepatic dysfunction/cholestasis, moderate AST/ALT elevation Clarithromycin:
Fatal drug-induced cholestasis associated with clarithromycin 500 mg bd for 3 days has been reported in a 59-year-old woman with diabetes mellitus and chronic renal insufficiency (39)
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References Fatal drug-induced cholestasis associated with clarithromycin 500 mg bd for 3 days has been reported in a 59-year-old woman with diabetes mellitus and chronic renal insufficiency [46]
DILI has a worldwide estimated annual incidence between 14 to 19
Other causes of liver failure, such as viral hepatitis, autoimmune hepatitis, toxins, and heart failure, were excluded by appropriate diagnostic
The eradication of H
Although elevated liver enzymes and cholestatic hepatitis have been infrequently reported, comprehensive literature review reveals only 6
, randomized, double-blind clinical trials in patients with H
Do not prescribe clarithromycin to: People with severe hepatic impairment if renal impairment is also present
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