NEXTERONE is an antiarrhythmic agent indicated for treatment and prophylaxis of ventricular fibrillation (VF) and hemodynamically unstable ventricular tachycardia (VT) in patients refractory to Am Fam Physician
CLINICAL PRACTICE Must be administered where cardiac monitoring and defibrillation are available Must be administered by permanent Acute Care Centre staff assessed in medication delivery Loading dose followed by a continuous infusion: Prescribe a single loading dose of 5 mg/kg (max
One formulation contains the diluent polysorbate, which is a vasoactive solvent that can potentially cause hypotension
Need regular bloodwork, ophthalmic exams, and cardiac assessment
Amiodarone should only be administered via a central line unless there is absolutely no alternative to peripheral administration eg cardiac arrest, destabilising ventricular arrhythmia
Amiodarone was administered by continuous intravenous infusion to rats at dosages of 25 mg/kg per day, 50 mg/kg per day, or 100 mg/kg per day (about 0
Loading infusions: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min) Maintenance infusion: 540 mg over the remaining 18 hours (0
concentration should SAN FRANCISCO EMS AGENCY Effective: 03/01/15 0
2 g in max
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Intravenous amiodarone is a recognised treatment alternative for the conversion of atrial fibrillation to sinus rhythm
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Give amiodarone 300 mg IV (IO) for adult patients in cardiac arrest who are in VF/pVT after three shocks have been administered
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Withdraw same volume from glucose 5% IV bag as volume of amiodarone to be added - see table below
Extravasation is defined as the leakage or inadvertent administration of a vesicant drug or solution from a vein into the extravascular space
5 to 2 times the control (reference) value or by intermittent subcutaneous injection in a dose of 10,000 to 20,000 U every 12 h, adjusted to prolong the mid-interval (6 h after Intravenous amiodarone is a recognised treatment alternative for the conversion of atrial fibrillation to sinus rhythm
Asymptomatic blue-grey discolouration of exposed areas can also occur
It is also important to note that the captisol-based formulation of amiodarone is currently marketed only as a premixed infusion, not in Amiodarone injection contains iodine
Cardioversion via the IV route: The recommended protocol involves administering a single dose of 150 mg of amiodarone via the IV route over 10 minutes, followed by a continuous IV infusion at a rate of 1 mg/min for 6 hours, and subsequently reducing the infusion rate to 0
This skill delegates to the nurse the ability to make independent decisions and to implement actions according to protocol guidelines under medical directive
Depending on clinical situation and duration of AF, outpatient amiodarone may not Considered the preferred antiarrhythmic drug for this use in current ACLS guidelines in adults; lidocaine may be used as an alternative
Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhyth-mias and atrial fibrillation
Dosage Forms & Strengths Maintenance dose: 0
Amiodarone (Intravenous Route) Drug information provided by: Merative, Micromedex
Amiodarone: class III anti-arrhythmic; prolongs cardiac action potential & delaying refractory period IV - 30 & 50mg/mL ampoules; DOSE
Intravenous magnesium should also be considered (more discussion of this below)
AF maintenance of sinus: Oral: 400 - 600 mg/d (in divided doses) for 2-4 wk; maintenance dose is typically 100 - 200 mg/d
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Dilute with NS or D5%W to a concentration of 100 mg/ml
First, patients were treated with a magnesium infusion as previously described by Moran (0
A clear adhesive dressing was applied to cover the catheter insertion site
Appropriate use of this drug, with its severe and potentially life-threatening adverse effects, requires an essential understanding of its risk-benefit properties in order to ensure safety
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AMIODARONE (CORDARONE) INFUSION ORDERS Allergies:_ Height: _ Weight (kg): _ Attending Physician:_ A healthcare provider prescribes an IV infusion of 0
Rhythm control via the IV route: The recommended approach involves initiating a single 150 mg IV dose of amiodarone over
Amiodarone is an effective antiarrhythmic medication frequently used in practice for both ventricular and atrial arrhythmias
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Many of these effects are due to the tissue accumulation of amiodarone
A boy aged 11 months presented to his local hospital with a short history of
125 mcg/kg/min continuous IV infusion (maximum: 10 mcg/min) for 12 – 24 hours
Increasing the infusion concentration from 1
Antiarrhythmic drugs
Product Information: Activase(R) intravenous injection, alteplase intravenous injection
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At the first sign of extravasation, the following steps are recommended: (1) stop administration of IV fluids immediately, (2) disconnect the IV tube from the cannula, (3) aspirate any residual drug from the cannula, (4) administer a drug-specific antidote, and (5) notify the physician ( Fig
Check with your doctor or nurse immediately if any of the following side effects occur: More common
This may be given orally or intravenously depending on the clinical situation
The usual amiodarone dose in PAF is 200 mg daily
5 to 2 times the control (reference) value or by intermittent subcutaneous injection in a dose of 10,000 to 20,000 U every 12 h, adjusted to prolong the mid-interval (6 h after Intravenous amiodarone is a recognised treatment alternative for the conversion of atrial fibrillation to sinus rhythm
For continuous infusions that will exceed 2 hours, the solution must be prepared in polyolefin bag
Intravenous amiodarone is available in 2 approved formulations in the United States
2 micron filter IV set
Amiodarone PO dosing in hospital After converts to NSR or after 24 hrs, 400mg PO BID up to 10g load (includes IV), then 200mg daily
Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhyth-mias and atrial fibrillation
Initially 5microgram/minute adjusted according to response and heart rate
Amiodarone (Intravenous Route) Drug information provided by: Merative, Micromedex