In dialysis patients, both oral and parenteral forms suppress PTH, having an activity similar to calcitriol
DOXERCALCIFEROL - ORAL (dox-er-kal-SIF-e-role) COMMON BRAND NAME(S): Hectorol
Peak blood levels of 1α,25-(OH) 2D 2 are reached at 8 +/- 5
Results: The predicted conversion factor for paricalcitol
0 is appropriate when converting from IV paricalcitol to oral doxercalciferol and a conversion factor of 1
Doxercalciferol is a synthetic (man- made) form of vitamin D
25 mcg = 1 mcg paricalcitol) 3 times a week from intravenous paricalcitol
A potential mechanism is the conversion of high levels of 1α-D 2 to 1,24-dihydroxy D2, a compound with lower calcemic activity than calcitriol (290, 359)
3 Calcitriol, especially in oral format, is the least costly of VDRA medication after conversion to oral calcitriol
25mcg/day at 4-8 week intervals, up to 0
5 mcg 3 times weekly approximately every other day or if necessary higher doses at 1 Europe, and Asia, including intravenous doxercalciferol,2 one-alpha hydroxycholecalciferol, and maxacalcitol
iPTH below 100 pg/mL: suspend dosing for 1 week, then resume at a dose at least 2
The mean elimination half-life of 1
Azulfidine
Drug information provided by: Merative, Micromedex
Deficiency of 1,25-dihydroxyvitamin D plays an important role in the pathogenesis of secondary hyperparathyroidism
PK !ï ‡¾ˆ [Content_Types]
Paricalcitol-treated patients achieved a > or =50% reduction from baseline PTH significantly faster than did the calcitriol-treated patients (P = 0
Hectorol is contraindicated in patients with known hypersensitivity to doxercalciferol or any of its inactive ingredients
1 The sterile, clear, colorless aqueous solution is supplied in a single-use, amber glass vial that contains either 2 mcg/1 mL or 4 mcg/2 mL
1 mcg/mL solution
Systemic calcitriol is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on
40 mcg/week after the conversion, which represents a 20% reduction in the active vitamin D 3 (P < 0
However, daily 0