1, and 0
15) Hence the dose equivalent to 200mg (one tenth of LD 50) of pure drug and ISSD suspension in the 0
2) (n = 3, mean ± SD)
The pH 7 formulations, where larger fraction of the drug was in solution
14) Dates
84 × 10 − 3 g/L), dimethylsulfoxide (59 g/L) and methylene chloride
| Find, read and cite all the research This work aims to mechanistically understand the oral absorption behavior for a weakly basic drug, Irbesartan (IRB), by investigating its pH dependent solubility
2) (n = 3, mean ± SD)
PDF | The objective of present work was to enhance the solubility and bioavailability of poorly aqueous soluble drug Irbesartan (IBS)
in solubility, dissolution rate and hence bioavailabilty of poorly water soluble drug Irbesartan
The optimum concentration for formation of irbesartan/cyclodextrin inclusion complex was found to be 10% (w/v) and the solubility of ionized irbesartan/γ
PMCID: PMC9760361
Thus, at pH $4 the drug is partly in its protonated form and partly in its unprotonated form and practically insoluble in water whereas at pH $7 the drug is partly unionized and
1 at
1016/j
@article{Muankaew2014EffectO, title={Effect of $\gamma$-cyclodextrin on solubilization and complexation of irbesartan: influence of pH and excipients
It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an EC 3
Solubility of Irbesartan in various co -surfactants Table -3: Solubility of Irbesartan in various co -surfactants
40 ( Figure 3) 25
4) with 40% ethanol was used as the receiver medium for in vitro release studies for 48 h by the dialysis method
However, several experimental
The nanoparticle formulation showed a prolonged improved drug release for 24 hours in phosphate buffer pH 6
5
The separation was best carried out using 60 mM sodium phosphate buffer (pH 2
188 µM by bead mill treatment
5°C at 50 rpm
In this study, a novel liquid SNEDDS containing Irbesartan was formulated and further developed into a solid form by spray drying technique using Aerosil 200 as The solubilities of sesquihydrous irbesartan hydrobromide in ethanol−water mixtures at pH 1
The affinity of irbesartan (IRB) to form inclusion complexes with β -cyclodextrin (β -CD), hydroxypropylβ -cyclodextrin (HP-β -CD), and γ -cyclodextrin (γ -CD) was investigated in aqueous buffered solutions at pH 1