However, because metformin is cleared from the body through the kidneys, there was concern that it would build up to toxic levels in people with CKD, and like phenformin, cause lactic acidosis
eGFR 25 to
Titrate according to response; 10 : Initially 2
Rare side effects of Glimepiride include: yellowing skin and eyes ( jaundice) Postmarketing side effects of Glimepiride reported include: serious hypersensitivity reactions failure
be and conservative maintenance at 1 mg daily
Glimepiride may cause prolonged hypoglycemia in patients with renal dysfunction, so the Metabolism is affected by renal failure, necessitating dosage reduction and eventually avoidance Glyburide (Micronase) 2
Fluid Introduction
Oral hydration as a safe prophylactic measure to prevent post-contrast acute kidney injury in oncologic patients with chronic kidney disease (IIIb) referred for contrast-enhanced computed tomography: subanalysis of the oncological group of the NICIR study
with glimepiride (1, 2, 4, and 8 mg once daily) than with placebo after 14 days of oral dosing
A single-dose, open-label study was conducted in 15 patients with renal impairment
Glimepiride (Amaryl) Glipizide (Glucotrol) Glyburide
Dosage adjustment required in renal Special Populations: Renal Function Impairment
73 m 2 and the dosage reduction should be 75% in Dosage in renal failure Metformin and glimepiride in BLISTO® TRIO are eliminated through the kidney, and the risk of complications like lactic acidosis is greater in patients with renal dysfunction
Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems
Randomization was stratified by baseline HbA1c (≤8% and >8%) and background antidiabetic therapy (insulin or any combination
Heart failure (HF) and diabetes mellitus (DM) often coexist