Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis
S
In this cohort study of 12 722 older adults, chlorthalidone use was associated with a higher risk for eGFR decline of 30% or more, cardiovascular events
At a median follow-up of 2
3 Department of Pharmacy, Medical University, Pleven, Bulgaria However, the molecular structure of CTLD allows Comparative efficacy and safety of chlorthalidone and
The main aim for this meta-analysis is to compare the efficacy of the combination of angiotensin receptor blocker (ARB) and chlorthalidone (CTLD) to the combination of ARB and hydrochlorothiazide (HCTZ) in patients with hypertension
The analysis shows that chlorthalidone reduced the serum potassium levels with WMD (95% CI) equal to −0
27 characterized the dose–response relationships for three commonly prescribed thiazide/thiazide-like diuretics, hydrochlorothiazide, chlorthalidone and bendroflumethiazide
Hypertension
A 2016 RCT (N = 54) evaluated the effect of low-dose chlorthalidone and hydrochlorothiazide on mean 24-hour In this random effects meta-analysis, we demonstrate the existence of results that strongly raise the hypothesis that thiazide and thiazide-like diuretics would be effective in reducing blood pressure, even in patients with stage 4 and 5 CKD, and that the threshold of 30 or 40 mL/min/1
Numerous classes of anti-hypertensive medications are available to treat high blood pressure
However, head-to-head trials testing the effect of the 2 drugs on cardiovascular events (CVEs) are lacking
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6, and 26
5 mg, respectively) and a urate increase of 36 μmol/l was found with a 12
This 52‐week, randomized, open‐label study evaluated long‐term safety/tolerability of fixed‐dose combination azilsartan medoxomil/chlorthalidone (AZL ‐M/ CLD) vs fixed‐dose combination olmesartan medoxomil/hydrochlorothiazide (OLM / HCTZ) in patients with essential hypertension (stage 2; clinic systolic blood pressure