Caroline Schmidt, MD
depression – the starting dose is 60mg, taken once a day and this can be increased to 120mg, taken once a day
If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines
7 Steady state concentrations have still been shown to be dose proportional with a doubling of dose from 30 to 60 mg and from 60 to 120 mg producing 2
Common side effects
Cymbalta only
Major depressive disorder (unipolar): Oral: Initial: 40 to 60 mg/day divided twice daily or given as a single daily dose
Common side effects are drowsiness, dyspepsia, nausea, headache, increased
You can find detailed information about this drug in the official Patient Information Leaflet (PIL)
However, dosages >60 mg daily apparently do not provide additional benefit
Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder
In the pediatric MDD, GAD, and fibromyalgia trials up to 40 weeks long, there were 988 duloxetine-treated pediatric patients aged 7 to 17 years of age (most patients received 30-120 mg per day) – 35% were 7 to
Common side effects may include: drowsiness; nausea, constipation, loss of appetite; dry mouth; or
Some patients may respond to the starting dosage