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2 The drug-mediated pH elevation also increases
There are potential cardiovascular side effects associated with its use
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Chloroquine and hydroxychloroquine are aminoquinoline derivatives widely used in the treatment of rheumatologic diseases as well as for malaria prophylaxis []
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Hydroxy-chloroquine prolongs spontaneous action potential Chloroquine (CQ) and hydroxychloroquine (HCQ) were widely adopted in treating COVID-19, but the results were contradictive
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Published guidance documents vary in their recommendations for monitoring and managing these potential
Initially used as antimalarials, Sudden death, most likely due to a malignant ventricular arrhythmia, occurred less than 2 months later
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Chloroquine (CQ) and its synthetic analog hydroxychloroquine (HCQ) have been widely used for malaria treatment, autoimmune diseases such as rheumatoid arthritis, and systemic lupus erythematosus
However, there is compelling evidence that chloroquine and hydroxychloroquine induce significant QTc prolongation and potentially increase the risk of arrhythmia… Either psychiatric symptoms or arrhythmia in COVID-19 patients undergoing steroid treatments have not been well described in the literature
However, chloroquine- or hydroxychloroquine-related cardiac disorder is a rare but severe adverse event, which can lead to death
Baseline QT interval should be measured, 15 particularly in those patients with risk factors 14, Chloroquine and hydroxychloroquine are 4-aminoquinoline compounds
Combining (hydroxy)chloroquine with these drugs might thus result in higher plasma levels and significant QT prolongation
67 mg chloroquine PHOSPHATE/mL (equivalent to 10 mg chloroquine BASE/mL) Oral Suspension If combined, monitor for QTc interval prolongation and ventricular arrhythmias
(Hydroxy)chloroquine ( (H)CQ) is being investigated as a treatment for COVID-19, but studies have so far demonstrated either no or a small benefit