Bergamottin was originally detected in the oil of bergamot (Citrus bergamia) as early as 1937 []
The inhibitory effect of bergamottin is also seen with P450s 3A5 and 2B6, although the kinactivation / Ki ratios are not as high as for P450 3A4 ( He et al
Red wine can cause dose dumping of extended-release As bergamottin demonstrated a robust inhibitory effect on SARS-CoV-2 infection, we sought to investigate the protective effect of bergamottin in the golden Syrian hamster model, which showed high susceptibility to infection and was a suitable animal model for the evaluation of antiviral drugs (Chan et al
The miR-145 mimic, control mimic, miR-145 inhibitor, control inhibitor, pcDNA 3
Bergamottin, lime juice, and red wine as inhibitors of cytochrome p450 3a4 activity: comparison with grapefruit juice
Furanocoumarins in grapefruit all originate from psoralen, and the major grapefruit furanocoumarins include bergaptol, bergapten, bergamottin, epoxybergamottin, and 6,7-dihydroxybergamottin
Bergamottin (50 mg/kg body mass) was intraperitoneally administrated to mice 12 h before injection of LPS, and the effect of bergamottin on LPS-induced ALI was evaluated
It is responsible for the systemic disposition of numerous structurally and pharmacologically unrelated lipophilic and amphipathic drugs
Supplementing with bergamot may help reduce inflammation, lower blood glucose, and help prevent cardiovascular disease
Of these, 45 were involved as victims (substrates) in interactions with marketed drugs (perpetrators)
Co-administration of grapefruit juice increases bioavailability of tacrolimus in liver transplant patients: a prospective study
P-glycoprotein is an important mediator of drug-drug interactions
Bergamottin has been reported to induce an apoptotic response in tumor cells (11,12)
Bergamottin (BG) and naringenin (NRG) could therefore be applied as markers in food-drug interaction studies in order to adjust posology and the dose of simvastatin should be accordingly reduced