For example, most isolates of Candida are susceptible to itraconazole, but this agent only recently became available as a parenteral preparation and has not been studied for “treatment of fluconazole-resistant serious invasive Candida infections (including C
56-1
Fluconazole is well established as a first-line management option for the treatment and prophylaxis of localized and systemic C
parapsilosis appear to possess persister cells that may become tolerant to drugs
However, the isolates were susceptible to voriconazole
parapsilosis and C
Clinical breakpoints for fungi v 9
Itraconazole (ITZ), a triazole antifungal agent, is a water-soluble orally active compound with a wide spectrum of antifungal activities
krusei, that are resistant to fluconazole and itraconazole
Alternatively, oral therapy with ketoconazole or itraconazole could be used for women suffering from Moreover, the doses of these drugs used were much higher for eradicating Candida krusei than the dosed used to treat C
Candida can be part of the human oral microbiota of up to 75% of persons without
tropicalis, C
krusei clinical isolates, including 6 synonymous mutations and 1 missense mutation (C44T)
Acceptable uses Treatment o Blastomycosis o Histoplasmosis Unacceptable uses Should be avoided in pregnancy We evaluated the susceptibilities to nine antifungal drugs of Candida parapsilosis species complex, Candida tropicalis, Candida glabrata species complex and Candida krusei isolates from patients with invasive candidiasis at 11 hospitals over 3 years
The most frequently diagnosed
IC50 values were determined by a broth microdilution method