Ketoconazole anti androgen mechanism

Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections. [89] [31] Examples include the CYP17A1 inhibitors ketoconazole , abiraterone acetate , and seviteronel , [89] the CYP11A1 (P450scc) inhibitor aminoglutethimide , [89] and the 5α-reductase inhibitors finasteride Feb 18, 2020 · Vardenafil: Ketoconazole (Systemic) may increase the serum concentration of Vardenafil

2024-03-19
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  1. 1990 )
  2. Mechanism of Action
  3. Ketoconazole, an FDA approved
  4. Early in their development, prostate cancers need androgens to grow
  5. This medicine may lower testosterone levels
  6. An increase in testosterone can make symptoms worse
  7. Thus, for more than 60 years