Higher results will be obtained when the blood is drawn at other times
Reporting Name Cyclosporine, B Container/Tube: Lavender top (EDTA) Specimen Volume: 3 mL
Cyclosporine, B Aliases CSA Level Gengraf Neoral Sandimmune (Cyclosporine) Monitoring whole blood cyclosporine concentration during therapy, particularly in
Cyclosporine is a lipophilic polypeptide used to prevent rejection after solid organ transplantation; it suppresses T-cell activation by inhibiting calcineurin to decrease
Routine: 1 day Test Schedule: Monday through Friday
Container/Tube: Lavender top (EDTA) Specimen Volume: 3 mL Collection Instructions: 1
dose
Test Code CYSPR Cyclosporine, Blood Reporting Name Cyclosporine, B Useful For
23
Cyclosporine is an immunosuppressive agent used to treat organ rejection post-transplant
Monitoring whole blood cyclosporine concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates
A Cyclosporine Blood Test is a test to assess the levels of cyclosporine in blood
Collect specimen immediately before a scheduled dose
It also has use in certain other autoimmune diseases, treatment of organ rejection in kidney, liver, and heart allogeneic transplants, rheumatoid arthritis when the condition has not adequately responded to methotrexate
Specimen Type: Whole blood
Dose is adjusted initially (up to 2 months posttransplant) to maintain concentrations generally between 150 and
Optimal blood drug levels are influenced by type of transplant, patient response, time posttransplant, coadministration of other drugs, and drug formulation
Clinical measurement of blood levels is required due to the inter-individual variability of metabolism as well as the toxicity associated with excessive dosage
Cyclosporine, Random
2 mL whole blood; full EDTA (lavender-top) tube
Additional Information: No definitive therapeutic or toxic ranges have been established for this peak testing
k
Most tests (except cyclosporine) require 0
Do not aliquot
Cyclosporine has a narrow therapeutic range with frequent adverse effects making therapeutic drug monitoring essential
Cyclosporine, B Useful For
Test Code CYSPR Cyclosporine, Blood Reporting Name Cyclosporine, B Useful For
cyclosporine, and oral contraceptives; where appropriate, the use of these drugs in patients on phenobarbital should be monitored clinically and through the laboratory
For bone marrow transplant, the therapeutic intervals vary with the type of transplant, that is allogeneic, unrelated, or syngeneic
Clinical Reference